Luke 22:42

42 saying, “Father, if you are willing, remove this cup from me. Nevertheless, not my will, but yours, be done.”

Matthew 20:22

22 Jesus answered, “You do not know what you are asking. Are you able to drink the cup that I am to drink?” They said to him, “We are able.”

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Matt. 18:1–20:34 The Community of the Messiah Revealed. This is the fourth of Jesus' five major discourses in Matthew's Gospel (see Introduction: Key Themes; Literary Features). As his earthly ministry draws to a close, Jesus has spent considerable time clarifying his identity and mission (chs. 14–17). He instructs his disciples on the nature of his covenant community, explaining the kingdom community's characteristics (18:1–35), its implications for the sanctity of marriage (19:1–12), and its value (19:13–20:34).

Matt. 19:1–20:34 Valuing the Kingdom Community. The great Galilean ministry has now ended, and Jesus and his disciples begin the momentous journey to Jerusalem. Jesus explains the sanctity of marriage (19:3–12) and reveals the tragedy of the rich young man (19:16–22), in contrast to the gracious reward awaiting those who follow him (19:23–30). This leads to the parable of the vineyard workers (20:1–16). Jesus then gives his third prediction of his death (20:17–19) and sets an example for community sacrifice, suffering, and service (20:20–28). As he and his disciples begin their ascent to Jerusalem, Jesus mercifully heals two blind men in Jericho (20:29–34).

Matt. 20:22–23 You. The plural pronoun indicates that Jesus addressed the mother and the brothers directly. The cup in Scripture is symbolic of one's divinely determined destiny, whether blessing (Ps. 16:5) or disaster (Jer. 25:15), salvation (Ps. 116:13) or wrath (Isa. 51:17). Here it refers to Jesus' forthcoming suffering (Matt. 26:39).